Preparation and assessment of prostaglandin E2 formulated with hydroxypropyl methyl cellulose and span 60 sustained release pessaries (vaginal suppositories)
نویسندگان
چکیده
منابع مشابه
Induction of labour with a sustained-release prostaglandin E2 vaginal pessary.
A new polymer vaginal pessary providing sustained constant release of prostaglandin E2 was administered to 66 patients before planned induction of labour. Effective ripening of the unfavourable cervix was achieved in each of 18 primigravidas, in eight of whom labour was initiated without further treatment. When the cervix was moderately favourable the need for orthodox induction of labour was o...
متن کاملInduction of labour using prostaglandin E2 pessaries.
The blanket use of prostaglandin E2 pessaries, as reported by Mr J H Shepherd and his colleagues (14 July, p 108), does concern me. While they did draw attention to the need for fetal monitoring in such patients, I wonder how satisfactorily this can be achieved, especially in relatively high-risk cases, under such circumstances and whether such monitoring could not be better achieved by direct...
متن کاملPreparation of Ethyl Cellulose Microspheres for Sustained Release of Sodium Bicarbonate
Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug re...
متن کاملPreparation of Ethyl Cellulose Microspheres for Sustained Release of Sodium Bicarbonate
Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsulated in ethyl cellulose microspheres by a novel solid-in-oil-in-oil (S/O/O) emulsification method using acetonitrile/soybean oil as new solvent pairs. Properties of the microspheres such as size, recovery rate, morphology, drug content, and drug re...
متن کاملIndomethacin sustained-release suppositories containing sugar ester.
We prepared indomethacin (IM) sustained-release suppositories using sugar ester (SE) as an additive. The suppositories were prepared by the fusion method with IM, SE, and Witepsol H-15 (H-15) and their availabilities in vitro and in vivo were evaluated mainly by the drug release test and the absorption test in rabbits, respectively. The softening point of the suppositories increased with increa...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Ethiopia
سال: 2018
ISSN: 1726-801X,1011-3924
DOI: 10.4314/bcse.v32i2.14